The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference. Prev. ed.: 2015.
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.
Table of Contents
PART 1 SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE SECTION A Anatomy and Development of the Respiratory Tract 1. Anatomy 2. Lung Growth and Development 3. Alveolar Compartment 4. Airway Biology 5. Lung Mesenchyme 6. Vascular Biology 7. Lymphatic Biology 8. Regeneration and Repair 9. Genetics of Lung Disease SECTION B Respiratory Physiology 10. Ventilation, Blood Flow, and Gas Exchange 11. Respiratory System Mechanics and Energetics 12. Acid-Base Balance 13. Aerosol and Drug Delivery 14. Pleural Physiology and Pathophysiology SECTION C Defense Mechanisms and Immunology 15. Innate Immunity 16. Adaptive Immunity 17. Microbiome PART 2 DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE SECTION D Diagnosis 18. History and Physical Examination 19. Microbiological Diagnosis of Lung Infection 20. Thoracic Radiology: Noninvasive Diagnostic Imaging 21. Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions 22. Pathology 23. Ultrasonography: Principles, and Basic Thoracic and Vascular Imaging 24. Ultrasonography: Advanced Applications and Procedures 25. Positron Emission Tomography 26. Diagnostic Bronchoscopy: Basic Techniques 27. Diagnostic Bronchoscopy: Advanced Techniques (EBUS and Navigational) 28. Therapeutic Bronchoscopy: Interventional Techniques 29. Thoracoscopy 30. Thoracic Surgery SECTION E Evaluation 31. Pulmonary Function Testing: Physiologic and technical principles 32. Pulmonary Function Testing: Interpretation and Applications 33. Exercise Testing 34. Preoperative Evaluation 35. Evaluation of Respiratory Impairment and Disability PART 3 CLINICAL RESPIRATORY MEDICINE SECTION F Evaluation of Common Presentations of Respiratory Disease 36. Dyspnea 37. Cough 38. Chest Pain 39. Wheezing and Stridor 40. Hemoptysis 41. Pulmonary Nodule 42. Positive Screening Test for Tuberculosis 43. Aspiration 44. Hypoxemia 45. Hypercarbia SECTION G Infectious Diseases of the Lungs 46. Community-Acquired Pneumonia 46a. COVID-19 47. Influenza 48. Hospital-Acquired Pneumonia 49. Ventilator-Associated Pneumonia 50. Lung Abscess 51. Tuberculosis: Epidemiology and Prevention 52. Tuberculosis: Pathogenesis and immunity 53. Tuberculosis: Clinical Manifestations and Diagnosis 54. Tuberculosis: Treatment of Drug-Susceptible and Drug-Resistant 55. Nontuberculous Mycobacterial Infections 56. Fungal Infections: Endemic 57. Fungal Infections: Opportunistic 58. Parasitic Infections 59. Outbreaks, Epidemics, and Bioterrorism SECTION H Obstructive Diseases 60. Asthma: Pathogenesis and Phenotypes 61. Asthma and Obesity 62. Asthma: Diagnosis and Management 63. COPD: Pathogenesis and Natural History 64. COPD: Diagnosis and Management 65. Smoking Hazards: Cigarettes, Vaping, Marijuana 66. Smoking Cessation 67. Cystic Fibrosis: Pathogenesis and Epidemiology 68. Cystic Fibrosis: Diagnosis and Management 69. Bronchiectasis 70. Upper Airway Disorders 71. Large Airway Disorders 72. Bronchiolitis SECTION I Neoplasms of the Lung 73. Lung Cancer: Molecular Biology and Targets 74. Lung Cancer: Epidemiology 75. Lung Cancer: Screening 76. Lung Cancer: Diagnosis and Staging 77. Lung Cancer: Treatment 78. Rare Primary Lung Tumors 79. Metastatic Malignant Tumors 80. Benign Lung Tumors SECTION J Disorders of the Pulmonary Circulation 81. Pulmonary Thromboembolism: Presentation and Diagnosis 82. Pulmonary Thromboembolism: Prophylaxis and Treatment 83. Pulmonary Hypertension: General Approach 84. Pulmonary Arterial Hypertension: Group 1 85. Pulmonary Hypertension due to Lung Disease: Group 3 86. Pulmonary Hypertension due to Chronic Thromboembolic Disease: Group 4 87. Pulmonary Vasculitis 88. Pulmonary Vascular Anomalies SECTION K Infiltrative and Interstitial Lung Diseases 89. Idiopathic Pulmonary Fibrosis 90. Nonspecific Interstitial Pneumonitis and Other Idiopathic Interstitial Pneumonias 91. Hypersensitivity Pneumonitis 92. Connective Tissue Diseases 93. Sarcoidosis 94. Diffuse Alveolar Hemorrhage 95. Pulmonary Langerhans Cell Histiocytosis and other Rare Diffuse Infiltrative Lung Diseases 96. Eosinophilic Lung Diseases 97. Lymphangioleiomyomatosis 98. Pulmonary Alveolar Proteinosis Syndromes 99. Drug-Induced Pulmonary Disease SECTION L Environmental and Occupational Hazards 100. Asthma in the Workplace 101. Pneumoconioses 102. Indoor and Outdoor Air Pollution 103. Acute Responses to Toxic Exposures 104. Trauma and Blast Injuries 105. High Altitude 106. Air Travel 107. Diving Medicine SECTION M Disorders of the Pleura 108. Pleural Effusions 109. Pleural Infections 110. Pneumothorax 111. Chylothorax 112. Pleural Fibrosis and Unexpandable Lung 113. Hemothorax 114. Pleural Malignancy SECTION N Disorders of the Mediastinum 115. Mediastinal Tumors and Cysts 116. Mediastinitis and Fibrosing Mediastinitis SECTION O Disorders of Sleep and Control of Breathing 117. Control of Breathing and Upper Airways During Sleep 118. Consequences of Sleep Disruption 119. Sleep-Disordered Breathing: General Approach 120. Obstructive Sleep Apnea 121. Central Sleep Apnea 122. Sleep-Disordered Breathing: Treatment SECTION P Respiratory Manifestations of Extrapulmonary Disorders 123. Pulmonary Complications of HIV Infection 124. Pulmonary Complications of Primary Immunodeficiencies 125. Pulmonary Complications of Stem Cell and Solid Organ Transplantation 126. Pulmonary Complications of Abdominal Diseases 127. Pulmonary Complications of Hematologic Diseases 128. Pulmonary Complications of Endocrine Diseases 129. The Lungs in Obstetric and Gynecologic Diseases 130. The Respiratory System and Neuromuscular Diseases 131. The Respiratory System and Chest Wall Diseases SECTION Q Management of Respiratory Failure 132. Acute Ventilatory Failure 133. Pulmonary Edema 134. Acute Respiratory Distress Syndrome 135. Mechanical Ventilation 136. Noninvasive Support of Ventilation 137. Noninvasive Support of Oxygenation 138. Extracorporeal Support of Gas Exchange 139. Pulmonary Rehabilitation 140. Lung Transplantation 141. End-of-Life Care in Respiratory Failure