Handbook of the Biology of Aging
(Handbooks of Aging)
Musi, Nicolas (EDT)
Hornsby, Peter (EDT)
Academic Pr 2015/09
576 p. 23 cm
エルゼビア社 心理学・神経科学 関連書 特集
The eighth edition of this very successful handbook on how basic aging processes and medical physiology affect biological systems includes new discussions of a variety of topics, including longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research and more. Prev. ed.: 2010.
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.
Table of Contents
Foreword Preface About the Editors List of Contributors Part I: Basic Mechanisms of Aging: Models and Systems Chapter 1. Longevity as a Complex Genetic Trait Introduction Defining the Aging Gene-Space Non-Genetic Sources of Complexity Emerging Tools for Studying Aging as a Complex Genetic Trait Conclusions References Chapter 2. The mTOR Pathway and Aging Introduction mTOR Signaling Pathway Genetic Modulation of Longevity by TOR Signaling in Model Organisms Rapamycin Rapalogs Potential Mechanisms of Life Span Extension by mTOR Inhibition mTOR in Age-Related Diseases Conclusion References Chapter 3. Sirtuins, Healthspan, and Longevity in Mammals Introduction Sirtuin-Driven Lifespan Extension in Invertebrates Sirtuin Enzymatic Activity Sirtuins and Mammalian Longevity Genetic Variation of Human Sirtuins Sirtuins as Modulators of Responses to CR Roles for Sirtuins in Diverse Disease States Cancer Metabolic Syndrome Cardiovascular Dysfunction Inflammatory Signaling Neurodegenerative Disease Sirtuin-Activating Compounds Conclusion Acknowledgments References Chapter 4. The Hypoxic Response and Aging Introduction The Hypoxic Response Hypoxic Signaling in Disease Physiological Roles for the Hypoxic Response A Direct Role for the Hypoxic Response in Aging Interactions with Other Longevity Pathways HIF in Mammalian Aging Positive Effects of Hypoxia Conclusion Acknowledgments References Chapter 5. The Role of Neurosensory Systems in the Modulation of Aging Introduction Peripheral Systems of Sensory Perception Environmental Sensing and the Regulation of Aging Mechanisms of Sensory-Mediated Lifespan Regulation The Next Steps in Mapping Sensory-Mediated Lifespan Circuits Synthesis and Perspectives References Chapter 6. The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan What Is a Naked Mole-Rat? Successful Aging Mechanisms in Successful Aging Summary References Chapter 7. Contributions of Telomere Biology to Human Age-Related Disease Introduction Telomere Structure and Function Telomerase Structure, Function, and Regulation Cellular Consequences of Telomere Dysfunction Age-Related Changes in Telomere Length Connections Between Human Age-Related Disease and Telomeres Prospects for Prognostication and Intervention Acknowledgments References Chapter 8. Systems Approaches to Understanding Aging Introduction Transcriptomic Approaches Toward Understanding Aging MicroRNA, Systems Biology, and Aging Epigenomics and Aging Integrated Microfluidic Systems for Studying Aging Conclusions Acknowledgments References Chapter 9. Integrative Genomics of Aging Introduction Post-Genome Technologies and Biogerontology Challenges in Data Analysis Data Integration Concluding Remarks Acknowledgments References Chapter 10. NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging Introduction Features of the ITP Experimental Design Types of Intervention Proposals Sought by the ITP Challenges Encountered Implementing Testing Protocols Summary of ITP Findings Stage II Studies The ITP at 10 Years: Synopsis and Future Goals References Chapter 11. Comparative Biology of Aging: Insights from Long-Lived Rodent Species Introduction Rodents as Models for Comparative Research Cross-Species Biological Comparisons NMRs and BMRs Comparative Genomics of Aging and Cancer Conclusion References Part II: The Pathobiology of Human Aging Chapter 12. Genetics of Human Aging Introduction Genetic Variation in Aging Phenotypes of Human Aging Experimental Models for Studying Human Aging Study Designs for Discovering Genes Related to Human Aging Genetic Linkage Analysis Genetic Association Analysis Genome-Wide Association Studies Rare Variants in Aging Candidate Studies in Aging Functional Analysis Summary and Perspectives References Chapter 13. The Aging Arterial Wall Introduction Proinflammatory Molecular Signature of the Aging Arterial Wall Macroscopic Age-associated Altered Arterial Cell Phenotypes Clinical Signs of Arterial Wall Aging Interaction of Aging, Hypertension, and Atherosclerosis Interventions on Arterial Wall Aging Concluding Remarks and Future Perspectives Acknowledgments References Chapter 14. Age-Related Alterations in Neural Plasticity Introduction Short (Milliseconds) Timeframe: Paired-Pulse Facilitation and Paired-Pulse Depression Intermediate (Seconds) Timeframe: Frequency Facilitation (FF) and the Post-Burst Afterhyperpolarization Long (Minutes to Days) Timeframe: Long-Term Potentiation and Long-Term Depression Neural Plasticity and the Calcium Dysregulation Hypothesis of Aging References Chapter 15. The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention Introduction Innate and Adaptive Immunity Age and Immunity Effect of Age on Hematopoiesis Effect of Age on Innate Immunity Effect of Age on Adaptive Immunity Immune Cell Function Clinical Consequences of Immunosenescence Effect of Age on Vaccination Immune Senescence and All-Cause Mortality Interventions to Restore Appropriate Immunity Perspectives References Chapter 16. Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms Introduction Progeria as a Model for Studying Vascular Disease Vascular Pathology in Progeria and Aging Atherosclerosis in Progeria and Aging ECM Changes in Progeria and Aging and Their Potential Contribution to Atherosclerosis Potential Molecular Mechanisms Driving Vascular Disease in Progeria Current Status of Clinical Intervention Trials for Progeria Concluding Remarks References Chapter 17. Cardiac Aging Introduction Cardiac Aging in Humans Murine Model of Cardiac Aging Molecular Mechanisms of Cardiac Aging Mechanisms of Progression to Heart Failure in Old Age Other Models of Cardiac Aging Interventions to Delay or Reverse Vertebrate Cardiac Aging References Chapter 18. Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity Introduction Dimensions of Morbidity The Length of Life Cycles and Population Health Trends in Population Prevalence of Physiological Dysregulation, Diseases and Conditions, Functioning Loss and Disability, and Life Expectancy Length of Life and Length of Healthy Life Conclusions References Chapter 19. On the Compression of Morbidity: From 1980 to 2015 and Beyond Introduction Themes and Paradigms Concluding Remarks References Author Index Subject Index