This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders. Prev. ed.: 2010.
For nearly 30 years, Dr. Meir Kryger's must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. For this updated 6th edition, extensive additional online material enhances the value of Principles and Practice of Sleep Medicine to your practice. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women's health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders. Online access to additional resources, including 95 video clips and over 950 self-assessment questions. The essential reference tool to manage and diagnose patients with sleep disorders.
Table of Contents
Section 1: Normal Sleep and Its Variance 1. History of Sleep Physiology and Medicine 2. Normal Human Sleep: An Overview 3. Normal Aging 4. Daytime Sleepiness and Alertness 5. Sleep Deprivation 6. Genetics of Normal Human Sleep Section 2: Sleep Mechanisms and Phylogeny 7. Neural Control of Sleep in Mammals 8. Rapid Eye Movement Sleep 9. Novel Techniques for identifying Sleep Mechanisms and Disorders 10. Sleep in Animals: A State of Adaptive Inactivity Section 3: Physiology in Sleep 11. Relevance of Sleep Physiology for Sleep Medicine Clinicians 12. What Brain Imaging Reveals about Sleep Generation and Maintenance? 13. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation 14. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders 15. Respiratory Physiology: Central Neural Control of Respiratory Neurons and Motoneurons during Sleep 16. Respiratory Physiology: Understanding the Control of Ventilation 17. Physiology of Upper and Lower Airways 18. Respiratory Physiology: Sleep at High Altitudes 19. Sleep and Host Defense 20. Endocrine Physiology in Relation to Sleep and Sleep Disturbances 21. Thermoregulation in Sleep and Hibernation 22. Memory Processing in Relation to Sleep 23. Sensory and Motor Processing During Sleep and Wakefulness 24. Opiate Action on Sleep and Breathing 25. Pathophysiology of Sleep-wake Disturbances After Traumatic Brain Injury Section 4: Genetics and Genomic Basis of Sleep 26. Introduction: Genetics and Genomics of Sleep 27. Genetics and Genomics of Circadian Clocks 28. Genetics and Genomic Basis of Sleep in Simple Model Organisms 29. Genetics and Genomic Basis of Sleep in Rodents 30. Genetics and Genomic Basis of Sleep in Healthy Humans 31. Genetics and Genomic Basis of Sleep Disorders in Humans Section 5: Chronobiology 32. Introduction: Master Circadian Clock and Master Circadian Rhythm 33. Anatomy of the Mammalian Circadian System 34. Physiology of the Mammalian Circadian System 35. Human Circadian Timing System and Sleep-Wake Regulation 36. Sleep Homeostasis and Models of Sleep Regulation 37. Circadian Rhythms in Sleepiness, Alertness, and Performance 38. Central and Peripheral Circadian Clocks 39. Circadian Dysregulation and Mental and Physical Health 40. Circadian Disorders of the Sleep-Wake Cycle Section 6: Pharmacology 41. Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects 42. Clinical Pharmacology of Other Drugs Used as Hypnotics 43. Wake-Promoting Medications: Basic Mechanisms and Pharmacology 44. Wake-Promoting Medications: Efficacy and Adverse Effects 45. Drugs That Disturb Sleep and Wakefulness 46. Effects of Hypnotic Drugs on Driving Performance Section 7: Psychobiology and Dreaming 47. Introduction 48. Why We Dream 49. Dream Content: Quantitative Findings 50. Brain Correlates of Sucessful Dream Recall 51. Neurobiology of Dreaming 52. Lucid Dreaming 53. Nightmares and Nightmare Function 54. Incorporation of waking Experiences into Dreams 55. Dreams and Nightmares in Posttraumatic Stress Disorder 56. Emotion, Motivation, and Reward in Relation to Dreaming Section 8: Impact, Presentation, and Diagnosis 57. Approach to the Patient with Disordered Sleep 58. Cardinal Manifestations of Sleep Disorders 59. Physical Examination in Sleep Medicine 60. Use of Clinical Tools and Tests in Sleep Medicine 61. Classification of Sleep Disorders 62. Epidemiology of Sleep Medicine 63. Sleep Medicine, Public Policy, and Public Health 64. Sleep and Athletic Performance Section 9: Legal Topics in Sleep Medicine 65. Sleep Forensics: Criminal Culpability for Sleep-Related Violence 66. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them 67. Legal Aspects of Fatigue-and Safety-Sensitive Professions 68. Sleep Medicine Clinical Practice and Compliance - United States 69. Sleep Medicine Clinical Practice and Compliance - Europe Section 10: Occupational Sleep Medicine 70. Introduction 71. Performance Deficits During Sleep Loss and Their Operational Consequences 72. Sleep and Performance Prediction Modeling 73. Fatigue Risk Management Systems 74. Drowsiness in Transportation Workers 75. Shift Work, Shift-Work Disorder, and Jet Lag 76. Sleep Problems in First Responders and in Deployed Military Personnel 77. Sleep, Occupational stress, and Burnout 78. Optimizing Shift Scheduling 79. Obstructive Sleep Apnea in the Workplace Section 11: Insonmnia 80. Insomnia: Recent Developments and Future Directions 81. Insomnia: Epidemiology and Risk Factors 82. Etiology and Pathophysiology of Insomnia 83. Insomnia Diagnosis Assessment, and Evaluation 84. Insomnia and Health 85. Cognitive Behavioral Therapies for Insomnia I: Approaches and Efficacy 86. Psychological and Behavioral Treatments for Insomnia II: Implementation and Specific Population 87. Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists 88. Pharmacologic Treatment of Insomnia: Other Medication Section 12: Neurological Disorders 89. Narcolepsy: Genetic, Immunology, and Pathophysiology 90. Narcolepsy: Diagnosis and Management 91. Idiopathic Hypersomnia 92. Parkinsonism 93. Sleep and Stroke 94. Sleep and Neuromuscular Diseases 95. Restless Legs Syndrome and Periodic Limb Movements During Sleep 96. Alzheimer's Disease and Other Dementias 97. Epilepsy, Sleep, and Sleep Disorders 98. Other Neurological Disorders 99. Sleep Disorders after Traumatic Brain Injury 100. Kleine-Levin Syndrome Section 13: Parasomnias 101. Parasomnias: Overview and Approach 102. Non-Rapid Eye Movement Parasomnias: Clinical Spectrum, Diagnostic Features, and Management 103. Rapid Eye Movement Sleep Parasomnias 104. Nightmares and Dream Disturbances 105. Other Parasomnias 106. Sleep-Related Movement Disorders and Their Unique Motor Manifestations Section 14: Sleep Breathing Disorders 107. Sleep Related Breathing Disorders: Classification 108. Sleep Breathing Disorders: Clinical Overview 109. Central Sleep Apnea: Definitions, and Pathophysiology, Genetics, and Epidemiology 110. Central Sleep Apnea: Diagnosis and Management 111. Anatomy and Physiology of Upper Airway Obstruction 112. Snoring and Pathologic Upper Airway Resistance Syndromes 113. Obstructive Sleep Apnea: Phenotypes and Genetics 114. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management 115. Positive Airway Pressure Treatment for Obstructive Sleep Apnea 116. Medical and Device Treatment for Obstructive Sleep Apnea: Alternative, Adjunctive, and Complementary Therapies 117. Obstructive Sleep Apnea and the Central Nervous System: Neural Adaptive Processes, Cognition and Performance 118. Obstructive Sleep Apnea and Metabolic Disorders 119. Overlap Syndromes of Sleep and Breathing Disorders 120. Obesity Hypoventilation Syndrome 121. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery 122. Sleep and Breathing at High Altitude Section 15: Cardiovascular Disorders 123. Sleep and Cardiovascular Disease: Present and Future 124. Sleep-Related Cardiac Risk 125. Cardiac Arrythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy 126. Cardiovascular Effects of Sleep-Related Breathing Disorders 127. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea 128 Coronary Artery Disease and Obstructive Sleep Apnea 129. Heart Failure Section 16: Other Medical Disorders 130. Sleep and Fatigue in Cancer Patients 131. Fibromyalgia and Chronic Fatigue Syndromes 132. Endocrine Disorders 133. Pain and Sleep 134. Sleep and Chronic Kidney Disease 135. Sleep in Critically Ill Patients Section 17: Psychiatric Disorders 136. Anxiety Disorders and Posttraumatic Stress Disorder 137. Unipolar Major Depression 138. Bipolar Disorder 139. Schizophrenia 140. Medication and Substance Abuse 141. Sleep Disturbances in Attention-Deficit/Hyperactivity Disorder Section 18: Dentistry and Otolaryngology in Sleep Medicine 142. Role of Dentistry and Otolaryngology in Sleep Medicine 143. Orophayngeal Growth & Skeletal Malformations 144. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences 145. Sleep Bruxism: Diagnostic Considerations 146. Orofacial Pain and Temporomandibular Disorders in Relation to Sleep-Disordered Breathing and Sleep Bruxism 147. Oral Appliances for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome and for Concomitant Sleep Bruxism 148. Anesthesia in Upper Airway Surgery for Obstructive Sleep Apnea 149. Upper Airway Surgery to Treat Obstructive sleep-Disordered Breathing 150. Pharmacotherapy, Complementary, Alternative Medicine for Sleep Bruxism Section 19: Sleep in Older Adults 151. Psychiatric and Medical Comorbidities, and Effects of Medications in Older Adults 152. Obstructive Sleep Apnea in Older Adults 153. Insomnia in Older Adults 154. Circadian Rhythms in Older Adults Section 20: Sleep in Women 155. Sex Differences and Menstrual-Related Changes in Sleep and Circadian Rhythms 156. Sleep and Sleep Disorders Associated with Pregnancy 157.Sleep-Disordered Breathing in Pregnancy 158. Postpartum Period and Early Motherhood 159. Sleep and Menopause Section 21: Instrumentation and Methodology 160. Polysomnography and Beyond 161. Sleep Stage Scoring 162. Central Nervous System Arousals & Cyclic Alternating Patterns 163. Neurologic Monitoring Techniques 164. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing Disorders 165. Home Sleep Testing 166. Cardiopulmonary Coupling Sleep Spectrograms 167. Pulse Wave Analysis During Sleep 168. Recording and Scoring Sleep-Related Movements 169. Evaluating Sleepiness 170. Chronobiologic Monitoring Techniques 171. Actigraphy