Stroke : Pathophysiology, Diagnosis, and Management
(Stroke Pathophysiology Diagnosis and Management)
Grotta. James C., M.D.
Albers, Gregory W., M.D.
Broderick, Joseph P., M.D.
Elsevier Science Health Science 2021/03
1151 p. 27 cm
Authored by the world's foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. You'll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine. Prev. ed.: 2015.
Authored by the world's foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You'll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today's stroke medicine. Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Keeps you abreast of the overwhelming volume of studies and guidelines in this dynamic field, providing clear summaries and practical evaluations of all relevant data. Contains updates throughout, including the latest clinical trials (thrombectomy, DAWN, DEFUSE), genetics research, prevention research, new therapies, and the new guidelines from the ASA. Includes new slides for lectures, covering basic science, case studies, and interventional treatment overviews. Features a Key Points summary at the beginning of each chapter so you can quickly find important information. Provides abundant full-color CT images and pathology slides that help you make efficient and accurate diagnoses. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Table of Contents
Section 1 Pathophysiology Introduction 1. Cerebral Vascular Biology in Health and Disease 2. Mechanisms of Thrombosis and Thrombolysis 3. Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease 4. Histopathology of Brain Tissue Response to Stroke and Injury 5. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death 6. Intracellular Signaling: Mediators and Protective Responses 7. The Neurovascular Unit and Responses to Ischemia 8. Mechanisms of Damage After Cerebral Hemorrhage 9. White Matter Pathophysiology 10. Cerebral Ischemia and Inflammation 11. Mechanisms of Plasticity, Remodeling and Recovery 12. Genetics and Vascular Biology of Brain Vascular Malformations 13. Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia Section 2 Epidemiology and Risk Factors Introduction 14. Global Burden of Stroke 15. Stroke Disparities 16. Risk Factors and Prevention 17. Prognosis after Stroke 18. Vascular Dementia and Cognitive Impairment 19. Genetic Basis of Stroke Occurrence, Prevention and Outcome Section 3 Clinical Manifestations Introduction 20. Classification of Ischemic Stroke 21. Clinical Scales to Assess Patients with Stroke 22. Carotid Artery Disease 23. Anterior Cerebral Artery Disease 24. Middle Cerebral Artery Disease 25. Posterior Cerebral Artery Disease 26. Vertebrobasilar Disease 27. Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease 28. Intracerebral Hemorrhage 29. Aneurysmal Subarachnoid Hemorrhage 30. Arteriovenous Malformations and Other Vascular Anomalies 31. Stroke and Other Vascular Syndromes of the Spinal Cord Section 4 Specific Conditions and Stroke Introduction 32. Cardiac Diseases 33. Atherosclerotic Disease of the Proximal Aorta 34. Stroke Related to Surgery and Other Procedures 35. Arterial Dissection, Fibromuscular Dysplasia, and Carotid Web 36. Inflammatory and Infectious Vasculopathies 37. Reversible Cerebral Vasoconstriction Syndromes 38. Posterior Reversible Encephalopathy Syndrome 39. Stroke and Substance Abuse 40. Moyamoya Disease 41. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 42. Hematologic Disorders and Stroke 43. Migraine and Stroke 44. Cryptogenic Stroke 45. Cerebral Venous Thrombosis Section 5 Diagnostic Studies Introduction 46. Ultrasonography 47. Computed Tomography-Based Evaluation of Cerebrovascular Disease 48. Magnetic Resonance Imaging of Cerebrovascular Diseases 49. Cerebral Angiography 50. OMICs in Stroke: Insight into stroke through epigenomics, transcriptomics, proteomics, lipidomics, and metabolomics Section 6 Therapy Part A: Medical Therapy Introduction 51. Stroke Systems of Care and Impact on Acute Stroke Treatment 52. Prehospital and Emergency Department Care of the Patient with Acute Stroke 53. Intravenous Thrombolysis 54. Antithrombotic Therapy for Treatment of Acute Ischemic Stroke 55. General Stroke Management and Stroke Units 56. Critical Care of the Patient with Acute Stroke, 57. Pharmacologic Modification of Acute Cerebral Ischemia 58. Treatment of "Other" Stroke Etiologies 59. Medical Therapy of Intracerebral and Intraventricular Hemorrhage 60. Rehabilitation and Recovery of the Patient with Stroke 61. Interventions to Improve Recovery after Stroke 62. Enhancing Stroke Recovery with Cellular Therapies 63. Antiplatelet Therapy for Secondary Prevention of Stroke 64. Secondary Prevention of Cardioembolic Stroke 65. Design of Stroke-Related Clinical Trials Part B: Interventional Therapy Introduction 66. Endovascular Therapy of Extracranial and Intracranial Occlusive Disease 67. Endovascular Treatment of Acute Ischemic Stroke 68. Endovascular Treatment of Intracranial Aneurysms 69. Interventional Therapy of Brain and Spinal Arteriovenous Malformations 70. Dural Arteriovenous Malformations Part C: Surgical Therapy Introduction 71. Surgery of Anterior and Posterior Aneurysms 72. Surgery for Intracerebral Hemorrhage 73. Management of Intraventricular Hemorrhage 74. Surgical Management of Cranial and Spinal Arteriovenous Malformations 75. Surgical Management of Cavernous Malformations and Venous Anomalies 76. Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis 77. Extracranial to Intracranial Bypass for Cerebral Ischemia 78. Decompressive Craniectomy for Infarction and Hemorrhage