書籍詳細

書籍詳細




洋書

創薬における構造生物学:手法・技術・事例

Structural Biology in Drug Discovery : Methods, Techniques, and Practices

Renaud, Jean-paul (EDT)

Wiley 2020/03
720 p. cm.   
装丁: Hrd    装丁について
テキストの言語: ENG    出版国: US
ISBN: 9781118681015
KCN: 1025105614
紀伊國屋書店 選定タイトル
標準価格:¥43,483(本体 ¥39,530)   
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納期について
DDC: 615
KDC: G451 薬学一般
G11 生化学・分子生物学
関連書リスト: SB3098F ワイリー 化学特集 2020
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Annotation

Presents the benefits, limitations, and potentiality of novel techniques in the field, like complex crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry.

Full Description

"This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural,thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher.