This comprehensive handbook is a compendium of the current state-of-the art of high field Dynamic Nuclear Polarization - from long-proven, early developments, up to today's hot topics.
Addresses Dynamic Nuclear Polarization (DNP) as a technique for sensitivity-enhancement in solid-state NMR spectroscopy This comprehensive handbook is a compendium of the current state-of-the art of high field Dynamic Nuclear Polarization--from long-proven, early developments, up to today's hot topics. It covers all the relevant subjects that have made a direct or indirect contribution toward advancing this field, and focuses on topics such as: the theory behind the effects seen within DNP; instrumentation required for carrying out DNP; and specific applications of DNP including protein monitoring, catalysis, nanoparticles, biological and clinical studies. Development and application of techniques that have indirectly contributed to advancing MAS DNP NMR, such as DNP experiments on static solids within microwave resonant structures, and high-field EPR, are also examined. Handbook of High Field Dynamic Nuclear Polarization is presented in three sections--Theoretical Aspects, DNP Development (instrumentation / radical / sample), and DNP NMR Applications. The first section offers chapters on; solid and cross effect DNP; thermal mixing; Overhauser; and dissolution DNP. The second looks at: microwave technology, gyrotron, and IOE; homebuilt and commercial DNP spectrometers; and glassing vs. solvent-free DNP. The final section provides information on; amyloid, membrane, and nanocrystalline proteins; metals, and surface enhanced DNP; pharmaceuticals; nanoparticles; and much more. Covers one of the biggest developing fields in magnetic resonance Relevant to students, academics, and industry within the physical, materials, medical, and biochemical sciences An excellent starting point and point-of-reference for researchers in the field Edited by a widely respected team with contributions from key researchers in the NMR community Part of the eMagRes Handbook Series Handbook of High Field Dynamic Nuclear Polarization is an ideal reference for all researchers and graduate students involved in this complex, interdisciplinary field. About eMagRes Handbooks eMagRes publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes
Table of Contents
Contributors xi Series Preface xvii Preface xix Acknowledgments xxi Part A: Concepts, Theory, & Instrumentation 1 1 The Discovery and Demonstration of Dynamic Nuclear Polarization-A Personal and Historical Account 3 Charles P. Slichter 2 DNP Mechanisms 15 Krishnendu Kundu, Frederic Mentink-Vigier, Akiva Feintuch, and Shimon Vega 3 Pulsed Dynamic Nuclear Polarization 71 Kong Ooi Tan, Sudheer Jawla, Richard J. Temkin, and Robert G. Griffin 4 MAS-DNP Enhancements: Hyperpolarization, Depolarization, and Absolute Sensitivity 87 Sabine Hediger, Daniel Lee, Frederic Mentink-Vigier, and Gael De Paepe 5 Polarizing Agents: Evolution and Outlook in Free Radical Development for DNP 103 Gilles Casano, Hakim Karoui, and Olivier Ouari 6 Paramagnetic Metal Ions for Dynamic Nuclear Polarization 121 Bjoern Corzilius 7 Instrumentation for High-field Dynamic Nuclear Polarization NMR Spectroscopy 143 Guy M. Bernard and Vladimir K. Michaelis 8 Millimeter-wave Sources for DNP-NMR 155 Monica Blank and Kevin L. Felch 9 Cryogenic Platforms and Optimized DNP Sensitivity 169 Yoh Matsuki and Toshimichi Fujiwara 10 Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities 189 Alisa Leavesley, Ilia Kaminker, and Songi Han 11 Dissolution Dynamic Nuclear Polarization Methodology and Instrumentation 219 Dennis Kurzbach and Sami Jannin 12 Introduction to Dissolution DNP: Overview, Instrumentation, and Human Applications 239 Jan H. Ardenkjaer-Larsen 13 Liquid-state Overhauser DNP at High Magnetic Fields 261 Vasyl P. Denysenkov and Thomas F. Prisner 14 Overhauser DNP in Liquids on 13C Nuclei 279 Marina Bennati and Tomas Orlando Part B: Applications 289 15 DNP and Cellular Solid-state NMR 291 Alessandra Lucini Paioni, Marie A.M. Renault, and Marc Baldus 16 Cryo-trapped Intermediates of Retinal Proteins Studied by DNP-enhanced MAS NMR Spectroscopy 305 Johanna Becker-Baldus and Clemens Glaubitz 17 DNP Solid-state NMR of Biological Membranes 323 Burkhard Bechinger 18 DNP in Materials Science: Touching the Surface 337 Pierrick Berruyer, Lyndon Emsley, and Anne Lesage 19 Growing Signals from the Noise: Challenging Nuclei in Materials DNP 353 Frederic A. Perras, Takeshi Kobayashi, and Marek Pruski 20 DNP-enhanced Solid-state NMR Spectroscopy of Active Pharmaceutical Ingredients 373 Li Zhao, Arthur C. Pinon, Lyndon Emsley, and Aaron J. Rossini 21 In Vivo Hyperpolarized 13C MRS and MRI Applications 405 Irene Marco-Rius and Arnaud Comment 22 Dissolution Dynamic Nuclear Polarization 421 Walter Koeckenberger Index 435