書籍詳細

書籍詳細




洋書

創薬における生体分子シミュレーション

Biomolecular Simulations in Drug Discovery

1. Auflage.

(Methods and Principles in Medicinal Chemistry)

Gervasio, Francesco L.   Spiwok, Vojtech   Mannhold, Raimund

Wiley-Vch 2019/02
448 p.   
装丁: Hrd    装丁について
テキストの言語: ENG    出版国: US
ISBN: 9783527342655
KCN: 1032135221
紀伊國屋書店 選定タイトル
標準価格:¥28,006(本体 ¥25,460)   
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納期について
KDC: G451 薬学一般
関連書リスト: SB3098F ワイリー 化学特集 2020
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Full Description

A guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.