Full Description

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

• Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
• Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
• Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
• Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
• Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
• PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.
• Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition.

Table of Contents

I Basic Principles in the Diagnosis and Management of Infectious Diseases A MICROBIAL PATHOGENESIS 1 A Molecular Perspective of Microbial Pathogenicity 2 The Human Microbiome of Local Body Sites and Their Unique Biology 3 Prebiotics, Probiotics, and Synbiotics B HOST DEFENSE MECHANISMS 4 Innate (General or Nonspecific) Host Defense Mechanisms 5 Adaptive Immunity: Antibodies and Immunodeficiencies 6 Cell-Mediated Defense Against Infection 7 Mucosal Immunity 8 Granulocytic Phagocytes 9 Complement and Deficiencies 10 Human Genetics and Infection 11 Nutrition, Immunity, and Infection 12 Evaluation of the Patient With Suspected Immunodeficiency C EPIDEMIOLOGY OF INFECTIOUS DISEASE 13 Applied Epidemiology for the Infectious Diseases Physician 14 Emerging and Reemerging Infectious Disease Threats 15 Bioterrorism: An Overview D CLINICAL MICROBIOLOGY 16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation E ANTIINFECTIVE THERAPY 17 Principles of Antiinfective Therapy 18 Molecular Mechanisms of Antibiotic Resistance in Bacteria 19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents 20 Penicillins and ß-Lactamase Inhibitors 21 Cephalosporins 22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam 23 Antibiotic Allergy 24 Fusidic Acid 25 Aminoglycosides 26 Tetracyclines, Glycylcyclines, and Chloramphenicol 27 Rifamycins 28 Metronidazole 29 Macrolides and Clindamycin 30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin) 31 Daptomycin and Quinupristin-Dalfopristin 32 Polymyxins (Polymyxin B and Colistin) 33 Linezolid, Tedizolid, and Other Oxazolidinones 34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole 35 Quinolones 36 Unique Antibacterial Agents 37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine 38 Topical Antibacterials 39 Antimycobacterial Agents 40A Antifungal Agents: Amphotericin B 40B Antifungal Drugs: Azoles 40C Antifungal Drugs: Echinocandins 40D Antifungal Drugs: Flucytosine 41 Antimalarial Drugs 42 Drugs for Protozoal Infections Other Than Malaria 43 Drugs for Helminths 44 Antiviral Agents: General Principles 45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections 46 Antivirals Against Herpesviruses 47 Antiviral Drugs Against Hepatitis Viruses 48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril) 49 Immunomodulators 50 Hyperbaric Oxygen 51 Antimicrobial Stewardship 52 Designing and Interpreting Clinical Studies in Infectious Diseases 53 Outpatient Parenteral Antimicrobial Therapy 54 Tables of Antiinfective Agent Pharmacology II Major Clinical Syndromes A FEVER 55 Temperature Regulation and the Pathogenesis of Fever 56 Fever of Unknown Origin 57 The Acutely Ill Patient With Fever and Rash B UPPER RESPIRATORY TRACT INFECTIONS 58 The Common Cold 59 Pharyngitis 60 Acute Laryngitis 61 Otitis Externa, Otitis Media, and Mastoiditis 62 Sinusitis 63 Epiglottitis 64 Infections of the Oral Cavity, Neck, and Head C PLEUROPULMONARY AND BRONCHIAL INFECTIONS 65 Acute Bronchitis 66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease 67 Acute Pneumonia 68 Pleural Effusion and Empyema 69 Bacterial Lung Abscess 70 Chronic Pneumonia 71 Cystic Fibrosis D URINARY TRACT INFECTIONS 72 Urinary Tract Infections E SEPSIS 73 Sepsis and Septic Shock F INTRAABDOMINAL INFECTIONS 74 Peritonitis and Intraperitoneal Abscesses 75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis) 76 Pancreatic Infection 77 Splenic Abscess 78 Appendicitis 79 Diverticulitis and Neutropenic Enterocolitis G CARDIOVASCULAR INFECTIONS 80 Endocarditis and Intravascular Infections 81 Prosthetic Valve Endocarditis 82 Infections of Nonvalvular Cardiovascular Devices 83 Prevention of Infective Endocarditis 84 Myocarditis and Pericarditis 85 Mediastinitis H CENTRAL NERVOUS SYSTEM INFECTIONS 86 Approach to the Patient With Central Nervous System Infection 87 Acute Meningitis 88 Chronic Meningitis 89 Encephalitis 90 Brain Abscess 91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis 92 Cerebrospinal Fluid Shunt and Drain Infections I SKIN AND SOFT TISSUE INFECTIONS 93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections 94 Myositis and Myonecrosis 95 Lymphadenitis and Lymphangitis J GASTROINTESTINAL INFECTIONS AND FOOD POISONING 96 Syndromes of Enteric Infection 97 Esophagitis 98 Diarrhea With Little or No Fever 99 Acute Dysentery Syndromes (Diarrhea With Fever) 100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers 101 Foodborne Disease 102 Tropical Sprue and Environmental Enteric Dysfunction K BONE AND JOINT INFECTIONS 103 Infectious Arthritis of Native Joints 104 Osteomyelitis 105 Orthopedic Implant–Associated Infections L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES 106 Genital Skin and Mucous Membrane Lesions 107 Urethritis 108 Vulvovaginitis and Cervicitis 109 Infections of the Female Pelvis 110 Prostatitis, Epididymitis, and Orchitis M EYE INFECTIONS 111 Introduction to Eye Infections 112 Microbial Conjunctivitis 113 Microbial Keratitis 114 Endophthalmitis 115 Infectious Causes of Uveitis 116 Periocular Infections N HEPATITIS 117 Viral Hepatitis O ACQUIRED IMMUNODEFICIENCY SYNDROME 118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome 119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development 120 Diagnosis of Human Immunodeficiency Virus Infection 121 The Immunology of Human Immunodeficiency Virus Infection 122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases) 123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection 124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection 125 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections 126 Human Immunodeficiency Virus Infection in Women 127 Pediatric Human Immunodeficiency Virus Infection 128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection 129 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection P MISCELLANEOUS SYNDROMES 130 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease) III Infectious Diseases and Their Etiologic Agents A VIRAL DISEASES 131 Biology of Viruses and Viral Diseases 132 Orthopoxviruses Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox 133 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses 134 Introduction to Herpesviridae 135 Herpes Simplex Virus 136 Chickenpox and Herpes Zoster (Varicella-Zoster Virus) 137 Cytomegalovirus 138 Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases) 139 Human Herpesvirus Types 6 and 7 (Exanthem Subitum) 140 Kaposi Sarcoma–Associated Herpesvirus (Human Herpesvirus 8) 141 Herpes B Virus 142 Adenoviruses 143 Papillomaviruses 144 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML) 145 Hepatitis B Virus 146 Hepatitis Delta Virus 147 Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses 148 Orthoreoviruses and Orbiviruses 149 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses 150 Rotaviruses 151 Alphaviruses (Chikungunya, Eastern Equine Encephalitis) 152 Rubella Virus (German Measles) 153 Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika) 154 Hepatitis C 155 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) 156 Parainfluenza Viruses 157 Mumps Virus 158 Respiratory Syncytial Virus 159 Human Metapneumovirus 160 Measles Virus (Rubeola) 161 Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses 162 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus) 163 Rabies (Rhabdoviruses) 164 Marburg and Ebola Virus Hemorrhagic Fevers 165 Influenza Viruses, Including Avian Influenza and Swine Influenza 166 California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers 167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses) 168 Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2) 169 Human Immunodeficiency Viruses 170 Introduction to the Human Enteroviruses and Parechoviruses 171 Poliovirus 172 Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70) 173 Parechoviruses 174 Hepatitis A Virus 175 Rhinovirus 176 Noroviruses and Sapoviruses (Caliciviruses) 177 Astroviruses and Picobirnaviruses 178 Hepatitis E Virus B PRION DISEASES 179 Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases) C CHLAMYDIAL DISEASES 180 Chlamydia trachomatis (Trachoma and Urogenital Infections) 181 Psittacosis (Due to Chlamydia psittaci) 182 Chlamydia pneumoniae D MYCOPLASMA DISEASES 183 Mycoplasma pneumoniae and Atypical Pneumonia 184 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species E RICKETTSIOSES, EHRLICHIOSES, AND ANAPLASMOSES 185 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses 186 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers) 187 Rickettsia akari (Rickettsialpox) 188 Coxiella burnetii (Q Fever) 189 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus) 190 Rickettsia typhi (Murine Typhus) 191 Orientia tsutsugamushi (Scrub Typhus) 192 Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae F BACTERIAL DISEASES 193 Introduction to Bacteria and Bacterial Diseases 194 Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome) 195 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci 196 Classification of Streptococci 197 Streptococcus pyogenes 198 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis 199 Streptococcus pneumoniae 200 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species 201 Streptococcus agalactiae (Group B Streptococci) 202 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci 203 Streptococcus anginosus Group 204 Corynebacterium diphtheriae (Diphtheria) 205 Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci 206 Listeria monocytogenes 207 Bacillus anthracis (Anthrax) 208 Bacillus Species and Related Genera Other Than Bacillus anthracis 209 Erysipelothrix Rhusiopathiae 210 Whipple Disease 211 Neisseria meningitidis 212 Neisseria gonorrhoeae (Gonorrhea) 213 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci 214 Vibrio cholerae 215 Other Pathogenic Vibrios 216 Campylobacter jejuni and Related Species 217 Helicobacter pylori and Other Gastric Helicobacter Species 218 Enterobacteriaceae 219 Pseudomonas aeruginosa and Other Pseudomonas Species 220 Stenotrophomonas maltophilia and Burkholderia cepacia Complex 221 Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders 222 Acinetobacter Species 223 Salmonella Species 224 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli 225 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid) 226 Brucellosis (Brucella Species) 227 Francisella tularensis (Tularemia) 228 Pasteurella Species 229A Plague (Yersinia pestis) 229B Yersinia enterocolitica and Yersinia pseudotuberculosis 230 Bordetella pertussis 231 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus 232 Legionnaires’ Disease and Pontiac Fever 233 Capnocytophaga 234 Bartonella, Including Cat-Scratch Disease 235 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale) 236 Other Gram-Negative and Gram-Variable Bacilli 237 Syphilis (Treponema pallidum) 238 Endemic Treponematoses 239 Leptospira Species (Leptospirosis) 240 Relapsing Fever Caused by Borrelia Species 241 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi 242 Anaerobic Infections: General Concepts 243 Clostridioides difficile (Formerly Clostridium difficile) Infection 244 Tetanus (Clostridium tetani) 245 Botulism (Clostridium botulinum) 246 Diseases Caused by Clostridium 247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli) 248 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli 249 Mycobacterium tuberculosis 250 Leprosy (Mycobacterium leprae) 251 Mycobacterium avium Complex 252 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex 253 Nocardia Species 254 Agents of Actinomycosis G MYCOSES 255 Introduction to Mycoses 256 Candida Species 257 Aspergillus Species 258 Agents of Mucormycosis and Entomophthoramycosis 259 Sporothrix schenckii 260 Agents of Chromoblastomycosis 261 Agents of Mycetoma 262 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii) 263 Histoplasma capsulatum (Histoplasmosis) 264 Blastomycosis 265 Coccidioidomycosis (Coccidioides Species) 266 Dermatophytosis (Ringworm) and Other Superficial Mycoses 267 Paracoccidioidomycosis 268 Uncommon Fungi and Related Species 269 Pneumocystis Species 270 Microsporidiosis H PROTOZOAL DISEASES 271 Introduction to Protozoal Diseases 272 Entamoeba Species, Including Amebic Colitis and Liver Abscess 273 Free-Living Amebae 274 Malaria (Plasmodium Species) 275 Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis 276 Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes 277 Agents of African Trypanosomiasis (Sleeping Sickness) 278 Toxoplasma gondii 279 Giardia lamblia 280 Trichomonas vaginalis 281 Babesia Species 282 Cryptosporidiosis (Cryptosporidium Species) 283 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species I DISEASES DUE TO TOXIC ALGAE 284 Human Illness Associated With Harmful Algal Blooms J DISEASES DUE TO HELMINTHS 285 Introduction to Helminth Infections 286 Intestinal Nematodes (Roundworms) 287 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis 288 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes) 289 Tapeworms (Cestodes) 290 Visceral Larva Migrans and Other Uncommon Helminth Infections K ECTOPARASITIC DISEASES 291 Introduction to Ectoparasitic Diseases 292 Lice (Pediculosis) 293 Scabies 294 Myiasis and Tungiasis 295 Mites, Including Chiggers 296 Ticks, Including Tick Paralysis L DISEASES OF UNKNOWN ETIOLOGY 297 Kawasaki Disease IV Special Problems A NOSOCOMIAL INFECTIONS 298 Infection Prevention and Control in the Health Care Setting 299 Disinfection, Sterilization, and Control of Hospital Waste 300 Infections Caused by Percutaneous Intravascular Devices 301 Nosocomial Pneumonia 302 Health Care–Associated Urinary Tract Infections 303 Health Care–Acquired Hepatitis 304 Transfusion- and Transplantation-Transmitted Infections B INFECTIONS IN SPECIAL HOSTS 305 Infections in the Immunocompromised Host: General Principles 306 Prophylaxis and Empirical Therapy of Infection in Cancer Patients 307 Infections in Recipients of Hematopoietic Stem Cell Transplants 308 Infections in Solid-Organ Transplant Recipients 309 Infections in Patients With Spinal Cord Injury 310 nfections in Older Adults 311 Infections in Asplenic Patients 312 Inf