Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.
The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.
Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.
The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
Table of Contents
PART 1 - Immunity Initiation, Propagation and Resolution of Inflammation.- Haematopoeisis and lymphocyte development: an introduction.- T cell subsets and T-cell mediated immunity.- Antibody diversity and B-cell mediated immunity.- Dendritic cells.- Cytokines.- Epigenetic regulation of immunity.- Innate immunity: phagocytes, NK cells, and and humoral defence.- Inflammatory mediators and intracellular signalling.- Immune response in human pathology: infections caused by bacteria, viruses, fungi, and parasites.- Immune response in human pathology: hypersensitivity and autoimmunity.- Cancer immunity.- Neuroimmunoendocrinology. PART 2 - Immunodiagnosis Antibody detection.- Immunoassays.- Flow cytometry.- Microarrays.- Imaging Inflammation.- PART 3 - Immunotherapeutics.- Vaccines and adjuvants.- Plasma-derived immunoglobulins.- Monoclonal antibodies for the treatment of immune.- Anti-allergic drugs.- Drugs for the treatment of airway disease.- Immunotherapy in the management of asthma and other allergic conditions.- Immunostimulants in cancer therapy.- Immunomodulation in sepsis and infection.- Immunopharmacology of probiotics and prebiotics.- Mild plant and dietary immunomodulators.- Influence of antibacterial drugs on the immune system.- Cytotoxic drugs.- Immunosuppressives in transplant rejection.- Corticosteroids.- Non-steroidal anti-inflammatory drugs.- Disease-modifying antirheumatic drugs.- Drugs for soft tissue autoimmune disorders.- Cell and gene therapy of immune disorders.- PART 4 - Immunotoxicology Immunotoxicology 2017.