This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.
Table of Contents
Part 1: The Foundation of IBD Genetics, Human and Animal Studies.- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges.- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies.- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease.- Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease.- Complex Disease Genes and their Discovery.- The Genetics of Crohn's Disease.- Genetics of Ulcerative Colitis.- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases.- Molecular Profiling of IBD Subtypes/Response to Therapy.- Epigenetics of Inflammatory Bowel Disease.- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease.- Nod1 and Nod2 and the Immune Response to Bacteria.- The IL-23-Th17 Axis in Intestinal Inflammation.- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics.- The Epithelial Barrier.- Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli”.- Cytokines in Inflammatory Bowel Disease.- Part 4: Concluding Remarks and Future Perspectives.- Towards Personalized Therapy in Inflammatory Bowel Disease.- Index.