For nearly 50 years, Sleisenger & Fordtran’s Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you’ll quickly and easily find the information you need.
- Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more.
- Offers reliable coverage of key topics such as Barrett’s esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation.
- Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management.
- Employs a consistent, templated, format throughout for quick retrieval of information.
- Includes monthly updates online, as well as more than 20 procedural videos.
Table of Contents
VOLUME 1 Part I Biology of the Gastrointestinal tract 1 Cellular Growth and Neoplasia, 1 Ezra Burstein 2 Mucosal Immunology and Inflammation, 13 CIharles O. Elson and Phillip D. Smith 3 The Enteric Microbiota, 24 Eugene B. Chang and Purna Kashyap 4 Gut Sensory Transduction, 34 Diego V. Bohórquez and Rodger A. Liddle
Part II Nutrition in Gastroenterology 5 Nutritional Principles and Assessment of the Gastroenterology Patient, 52 Joel B. Mason 6 Nutritional Management, 74 Angela K. Pham and Stephen A. McClave 7 Obesity, 92 Rekha B. Kumar and Louis J. Aronne 8 Surgical and Endoscopic Treatment of Obesity, 101 Shelby Sullivan, Steven A. Edmundowicz, and John Magaña Morton 9 Feeding and Eating Disorders, 117 Debra K. Katzman and Mark L. Norris 10 Food Allergies, 133 J. Andrew Bird
Part III Symptoms, Signs, and Biopsychosocial Issues 11 Acute Abdominal Pain, 144 Frederick H. Millham 12 Chronic Abdominal Pain, 158 Joseph C. Yarze and Lawrence S. Friedman 13 Symptoms of Esophageal Disease, 168 Kenneth R. DeVault 14 Dyspepsia,177 Jan Tack 15 Nausea and Vomiting, 191 Arvind Rengarajan and C. Prakash Gyawali 16 Diarrhea, 204 Lawrence R. Schiller and Joseph H. Sellin 17 Intestinal Gas,224 Fernando Azpiroz 18 Fecal Incontinence,232 Satish S.C. Rao 19 Constipation,250 Johanna C. Iturrino and Anthony J. Lembo 20 Gastrointestinal Bleeding, 276 Thomas J. Savides and Dennis M. Jensen 21 Jaundice, 313 Steven D. Lidofsky 22 Biopsychosocial Issues in Gastroenterology,324 Douglas A. Drossman and Laurie Keefer 23 Factitious Gastrointestinal Disease,340 John S. Fordtran and Anahit A. Zeynalyan
Part IV topics Involving Multiple Organs 24 Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases, 350 Kimberly L. Pham and Ginat W. Mirowski 25 Cutaneous Manifestations of Gastrointestinal and Liver Diseases, 359 Lawrence A. Mark 26 Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine, 372 Kerry B. Dunbar and D. Rohan Jeyarajah 27 Abdominal Hernias and Gastric Volvulus, 381 D. Rohan Jeyarajah and Kerry B. Dunbar 28 Foreign Bodies, Bezoars, and Caustic Ingestions, 399 Patrick R. Pfau and Mark Benson 29 Abdominal Abscesses and Gastrointestinal Fistulas, 411 Gregory dePrisco, Scott Celinski, and Cedric W. Spak 30 Eosinophilic Disorders of the Gastrointestinal Tract, 424 Marc E. Rothenberg and Vidhya Kunnathur 31 Protein-Losing Gastroenteropathy, 435 David A. Greenwald 32 Gastrointestinal Lymphomas, 442 Praveen Ramakrishnan Geethakumari and Syed Mujtaba Rizvi 33 Gastrointestinal Stromal Tumors, 458 Margaret von Mehren 34 Neuroendocrine Tumors, 472 Jonathan R. Strosberg and Taymeyah Al-Toubah 35 Gastrointestinal Consequences of Infection with Human Immunodeficiency Virus, 498 C. Mel Wilcox 36 Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation, 510 Anne M. Larson, Rachel B. Issaka, and David M. Hockenbery 37 Gastrointestinal and Hepatic Manifestations of Systemic Diseases, 532 Frederick Weber 38 Vascular Lesions of the Gastrointestinal Tract, 561 Joann Kwah and Lawrence J. Brandt 39 Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm, 580 Jeffrey B. Matthews and Kiran Turaga 40 Gastrointestinal and Hepatic Disorders in the Pregnant Patient, 593 Shilpa Mehra and John F. Reinus 41 Acute and Chronic Gastrointestinal Side Effects of Radiation Therapy, 606 Jarred P. Tanksley, Christopher G. Willett, Brian G. Czito, and Manisha Palta 42 Preparation for and Complications of Gastrointestinal Endoscopy, 619 Aravind Sugumar and John J. Vargo II
Part V Esophagus 43 Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus,627 Ryan D. Madanick and Vishal Kaila 44 Esophageal Neuromuscular Function and Motility Disorders, 638 John E. Pandolfino and Peter J. Kahrilas 45 Esophageal Disorders Caused by Medications, Trauma, and Infection, 661 David A. Katzka 46 Gastroesophageal Reflux Disease, 670 Joel E. Richter and Michael F. Vaezi 47 Barrett Esophagus, 691 Stuart Jon Spechler and Rhonda F. Souza 48 Esophageal Tumors, 700 Hazem Hammad and Sachin Wani
Part VI Stomach and Duodenum 49 Anatomy, Histology and Developmental Anomalies of the Stomach and Duodenum, 720 M. Gaith Semrin 50 Gastric Neuromuscular Function and Neuromuscular Disorders, 735 Kenneth L. Koch 51 Gastric Secretion,764 Mitchell L. Schubert and Jonathan D. Kaunitz52 Gastritis and Gastropathy, 781 Mark Feldman, Pamela J. Jensen, and Colin W. Howden 53 Peptic Ulcer Disease, 806 Francis K.L. Chan and James Y.W. Lau 54 Adenocarcinoma of the Stomach and Other Gastric Tumors, 820 Michael Quante and Jan Bornschein
Part VII Pancreas 55 Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas, 842 Megha S. Mehta, Bradley A. Barth, and Sohail Z. Husain 56 Pancreatic Secretion, 853 Stephen J. Pandol 57 Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood, 862 David C. Whitcomb and Mark E. Lowe 58 Acute Pancreatitis, 893 Santhi Swaroop Vege 59 Chronic Pancreatitis, 917 Chris E. Forsmark 60 Pancreatic Cancer, Cystic Pancreatic Neoplasms, and Other Nonendocrine Pancreatic Tumors, 947 Bijal Modi and G. Thomas Shires 61 Endoscopic Treatment of Pancreatic Disease, 965 Ryan Law and Todd H. Baron
Part VIII Biliary tract 62 Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract, 973 Frederick J. Suchy and Cara L. Mack 63 Biliary Tract Motor Function and Dysfunction, 995 B. Joseph Elmunzer and Grace H. Elta 64 Bile Secretion and the Enterohepatic Circulation, 1001 Peter Fickert and Paul A. Dawson 65 Gallstone Disease, 1016 David Q.-H. Wang and Nezam H. Afdhal 66 Treatment of Gallstone Disease, 1047 Robert E. Glasgow 67 Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps, 1064 Karin L. Andersson and Lawrence S. Friedman 68 Primary and Secondary Sclerosing Cholangitis, 1077 Cynthia Levy and Christopher L. Bowlus 69 Tumors of the Bile Ducts, Gallbladder, and Ampulla, 1096 Sumera H. Rizvi and Gregory J. Gores 70 Endoscopic and Radiologic Treatment of Biliary Disease, 1113 Theodore W. James and Todd H. Baron
Part IX Liver 71 Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver,1129 Ricard Masia and Joseph Misdraji 72 Liver Physiology and Energy Metabolism, 1135 Namita Roy-Chowdhury and Jayanta Roy-Chowdhury73 Liver Chemistry and Function Tests, 1154 Daniel S. Pratt 74 Overview of Cirrhosis, 1164 Patrick S. Kamath and Vijay H. Shah 75 Hemochromatosis, 1172 Bruce R. Bacon and Robert E. Fleming 76 Wilson Disease, 1180 Eve A. Roberts 77 Other Inherited Metabolic Disorders of the Liver, 1189 James E. Squires and William F. Balistreri 78 Hepatitis A, 1210 Maria H. Sjogren and Joseph G. Cheatham 79 Hepatitis B, 1216 Harry L.A. Janssen and Scott Fung 80 Hepatitis C, 1243 Jacinta A. Holmes and Raymond T. Chung 81 Hepatitis D, 1283 Marc G. Ghany 82 Hepatitis E, 1292 Rakesh Aggarwal 83 Hepatitis Caused by Other Viruses, 1298 Jordan J. Feld 84 Bacterial, Parasitic, and Fungal Infections of the Liver, Including Liver Abscesses, 1303 Arthur Y. Kim and Raymond T. Chung 85 Vascular Diseases of the Liver, 1321 Filipe Gaio Nery and Dominique Charles Valla 86 Alcohol-Associated Liver Disease, 1336 Gyongyi Szabo and Craig J. McClain 87 Nonalcoholic Fatty Liver Disease, 1354 Dawn M. Torres and Stephen A. Harrison 88 Liver Disease Caused by Drugs, 1367 Shivakumar Chitturi, Narci C. Teoh, and Geoffrey C. Farrell 89 Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements, 1399 James H. Lewis 90 Autoimmune Hepatitis, 1415 Albert J. Czaja 91 Primary Biliary Cholangitis, 1433 John E. Eaton and Keith D. Lindor 92 Portal Hypertension and Variceal Bleeding, 1443 Vijay H. Shah and Patrick S. Kamath 93 Ascites and Spontaneous Bacterial Peritonitis, 1471 Elsa Solà and Pere Ginès 94 Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease, 1486 Shivang S. Mehta and Michael B. Fallon 95 Acute Liver Failure, 1499 John O’Grady and William Bernal 96 Hepatic Tumors and Cysts, 1509 Adrian M. Di Bisceglie and Alex S. Befeler 97 Liver Transplantation, 1533 Andres F. Carrion and Paul Martin
Part X Small and Large Intestine 98 Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine, 1551 Lee M. Bass and Barry K. Wershil 99 Small Intestinal Motor and Sensory Function and Dysfunction, 1580 Christopher K. Rayner and Patrick A. Hughes 100 Colonic Motor and Sensory Function and Dysfunction, 1595 Philip G. Dinning, Marcello Costa, and Simon J.H. Brookes 101 Intestinal Electrolyte Absorption and Secretion, 1611 Mrinalini C. Rao and Jayashree Sarathy 102 Digestion and Absorption of Carbohydrate, Protein, and Fat, 1636 Yangzom D. Bhutia and Vadivel Ganapathy 103 Digestion and Absorption of Micronutrients, 1657 Michelle Pearlman and Jaime Almandoz 104 Maldigestion and Malabsorption, 1677 Christoph Höegenauer and Heinz F. Hammer 105 Small Intestinal Bacterial Overgrowth, 1711 Brian E. Lacy and John K. DiBaise 106 Short Bowel Syndrome, 1720 Alan L. Buchman 107 Celiac Disease, 1736 Benjamin Lebwohl and Peter H.R. Green 108 Tropical Diarrhea and Malabsorption, 1756 Balakrishnan S. Ramakrishna 109 Whipple Disease, 1769 Matthias Maiwald, Axel von Herbay, and David A. Relman 110 Infectious Enteritis and Proctocolitis, 1779 Joanna M.P. Melia and Cynthia L. Sears 111 Food Poisoning, 1810 Jennifer Katz 112 Antibiotic-Associated Diarrhea and Clostridioides difficile Infection, 1818 Ciarán P. Kelly and Sahil Khanna 113 Intestinal Protozoa, 1834 Christopher D. Huston 114 Intestinal Worms, 1847 M. Nedim Ince and David E. Elliott 115 Epidemiology, Pathogenesis, and Diagnosis of Inflammatory Bowel Diseases, 1868 Gilaad G. Kaplan and Siew C. Ng 116 Management of Inflammatory Bowel Diseases, 1898 Ashwin N. Ananthakrishnan and Miguel D. Regueiro 117 Ileostomies, Colostomies, Pouches, and Anastomoses, 1930 Ahsan Raza and Farshid Araghizadeh 118 Intestinal Ischemia, 1944 Paul Feuerstadt and Lawrence J. Brandt 119 Intestinal Ulcerations, 1970 Blair Lewis and Daniel S. Mishkin 120 Appendicitis,1983 Martin Daniel Rosenthal and George S. Sarosi, Jr. 121 Diverticular Disease of the Colon, 1993 Taft P. Bhuket and Neil H. Stollman 122 Irritable Bowel Syndrome, 2008 Alexander C. Ford and Nicholas J. Talley 123 Intestinal Obstruction, 2021 William Conan Mustain and Richard H. Turnage 124 Ileus and Pseudo-Obstruction Syndromes, 2039 Adil E. Bharucha and David O. Prichard 125 Tumors of the Small Intestine, 2059 Boris Blechacz and Robert Scott Bresalier 126 Colonic Polyps and Polyposis Syndromes, 2076 John J. Garber and Daniel C. Chung 127 John J. Garber and Daniel C. Chung Colorectal Cancer, 2108 Robert Scott Bresalier 128 Other Diseases of the Colon, 2153 Darrell S. Pardi and Thomas G. Cotter 129 Anal Diseases, 2169 J. Marcus Downs and Benjamin Kulow
Part XI additional treatments for Patients with Gastrointestinal and Liver Disease 130 Probiotics, 2187 Eamonn M.M. Quigley 131 Complementary, Alternative, and Integrative Medicine, 2192 Jill K. Deutsch and David J. Hass 132 Palliative Care Medicine in Patients with Advanced Gastrointestinal and Hepatic Disease, 2206 Vyjeyanthi S. Periyakoil, Nielsen Fernandez-Becker, and Sarah E. Streett